Magnetic shaping of ferrite-PDMS composite and its application in magnetic particle targeting

• Main Authors: Yu-Min Yang, 楊煜民
• Other Authors: Yu-Chuan Su
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/00483191479291427256

碩士 === 國立清華大學 === 工程與系統科學系 === 96 === This work presents a structure forming scheme that is capable of remotely shaping magnetic composites into desired geometries. The magnetic composites, which are made up of fine ferrite particles in PDMS pre-polymer matrices, are injected into controlled magnetic fields and deformed by the induced magnetic and interfacial forces. Directed by the magnetic fields, the injected composites can be longitudinally extruded, wound around targeted structures and attached firmly to them. Once magnetically heated and solidified, the composite structures can potentially serve as implants to assist the targeting of magnetic particles. When energized by external magnetic fields, the implanted structures in turn produce short-ranged forces that can guide the targeting of nearby magnetic particles. As such, the desired internal attraction for magnetic carrier targeting can be achieved and switched on/off remotely, which localizes the retention of carriers, accelerates the release of drugs, and improves the therapeutic efficiency.