| Summary: | 碩士 === 國立清華大學 === 材料科學工程學系 === 96 === Technological concrete is a construction material commonly composed of water, cement and aggregate such as sand and gravel . The purpose of this study is to fabricate biomedical concrete for bone defect repair.
In this research, the roles of the cement, sand and gravel are respectivly Zn0.075Ca2.925SiO5, hydroxylapatite( HAp ) and�n��-tricalcium phosphate (��-TCP). Zn doped tricalcium silicate powders (Zn0.075Ca2.925SiO5) are prepared by calcining reagent-grade CaCO3, SiO2 and ZnO at 1400 oC through the solid-state reaction. And then the Zn0.075Ca2.925SiO5 powders are milled by high-energy ball milling to lower the particle size under 10 �慆. 10 wt% NaH2PO4 used as binder, furthermore, biological polymers, collagen and alginate, are added to improve the bio-compatibility of the biomedical concrete. The inorganic component ratio of the biomedical concrete is 1 : 2 : 4, and organic additives were 1 wt% collagen and 1 wt% alginate (named : G1). The biomedical concrete mixed with NaH2PO4 solution has proper 11 minutes working time and 90 minutes setting time. The compressive strength of the biomedical concrete is averagely 30~40 MPa. Pure Zn0.075Ca2.925SiO5 added with the same polymer content is prepared and serving as relative ( named : O1). G1 and O1 are further studied.
Mice fibroblast cell line ( L929 ) is cultured for in vitro test. In the cytotoxicity tests, G1 shows excellent bio-compatibility comparing to O1. In addition, for Animal test for Newland white rabbits in vivo, G1 shows good repairing ability.
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