Ring Rearrangement Metathesis of 2-Allybicyclo[2.2.2]octenes A Short Entry to cis-Hydroindenols from 2-Methoxyphenols
碩士 === 國立清華大學 === 化學系 === 96 === The cis-hydrindanol skeleton can be found in the structures of many natural products, such as Botrydial、Sesquiterpene and Presilphiperfolan-8b-ol. Thus, in this thesis we report a short entry to functionalized cis-Hydroindenols from Diels-Alder reactions with masked...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2008
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| Online Access: | http://ndltd.ncl.edu.tw/handle/59657954877965762076 |
| Summary: | 碩士 === 國立清華大學 === 化學系 === 96 === The cis-hydrindanol skeleton can be found in the structures of many natural products, such as Botrydial、Sesquiterpene and Presilphiperfolan-8b-ol. Thus, in this thesis we report a short entry to functionalized cis-Hydroindenols from Diels-Alder reactions with masked o-benzoquinone (MOB) and the Ring- Rearrangement Metathesis (RRM).The bicyclo[2.2.2]octenone derivatives prepared for the RRM reaction were obtained from the Diels-Alder reaction of MOBs with various dienophiles, and followed by the addition of allylmagnesium bromide-CeCl3 complex. We have then successfully constructed cis-hydrindanol skeleton by this strategy and explored the scope and limitation of the target synthetic method.
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