Effects of Different Degrees of Weight Loss to Promote the Insulin Sensitivity in Non-Obesity

• Main Authors: Chiu-Hung Shen, 沈秋宏
• Other Authors: Hsiang-Chu Leu
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/47424536435705766095

碩士 === 國立臺中教育大學 === 體育學系碩士班 === 96 === Because of the adipocyte which accumulated abundant of fat might impair insulin signal transduction function by secreting adipokines or cytokines, and consequently induce the insulin resistance. Thus, the purpose of this study was to investigate whether the insulin sensitivity of adults, whose weights were 6 kg heavier than they were young but yet had not reached the obesity degree, would be more sensitive and their blood profiles concerning the metabolism syndrome would be better, after they lost their weight at 2 kg and 4 kg . Only six females ( 48.17 ± 10.07 yrs, BMI 24.01 ± 1.38 kg/m2, waist circum 77.50 ± 6.32 cm) succeeded in losing 4 kg by exercise combining with moderate energy-restricted diet during 16 weeks. The results were shown as follows: (1) Insulin and insulin sensitivity index aspect: The insulin level of the subjects were 6.51 ± 1.58 mU/l, 6.32 ± 1.62 mU/l and 4.96 ± 1.13 mU/l at pre-test, 2 kg , and 4 kg , respectively (reduced 2.91% at 2 kg, 23.84% at 4 kg). The HOMA index were 1.57 ± 0.38, 1.49 ± 0.46 and 1.10 ± 0.32 (－5.09％, －30.12％); the QUICKI index were 0.359 ± 0.015, 0.363 ± 0.020 and 0.381 ± 0.021(＋1.11％, ＋6.28％); the McAuley index were 7.99 ± 0.8, 8.33 ± 0.8 and 9.14 ± 0.68 (＋4.26％; ＋14.46％). By dependent event of the one-way ANOVA analysis to test these four variables, the results all reached the level of significance (p<.05). Posteriori comparisons of the Fisher’s Least Significant Difference to test the insulin had the consistent results. Namely, the HOMA index and the QUICKI index did not reach the significant differences in the 2kg reduction stage but reached the significant differences in the stage of 2 kg to 4 kg reduction and in the stage of 4 kg reduction. Furthermore, the McAuley indexs all reached the significant differences in each stage. (2) The blood profiles concerning the metabolism syndrome Except the blood pressure, the blood glucose, TC, HDL-C, LDL-C, TG at 2 kg and 4 kg were all significant better (p< .05) than pre-test. Conclusion: The insulin sensitivity of the adults who were non-obesity and no metabolism syndrome might be induced, and their blood profiles concerning the metabolism syndrome might become better after they lose their weight more than 2 kg.