A PET 4-[18F]-ADAM study in drug-naive depression patients and healthy human subjects

• Main Authors: CHung,YU-Chen, 鍾玉禎
• Other Authors: MA KUO-HSING
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/57198962780630866454

碩士 === 國防醫學院 === 生物及解剖學研究所 === 96 === Objectives: Serotonin transporters (SERT) play a major role in modulating serotonergic neuronal function. The study was undertaken to image central SERT using 4-[18F]-ADAM PET in healthy and drug naïve depressant subjects. Methods: In the Tri-Service General Hospital: 5 healthy (2 man and 3 woman, mean age: 29 y) and 11 naive depressant subjects (4 man and 7 woman, mean age: 34 y). In the Veterans General Hospital: 4 healthy 3 man and 1 woman, mean age: 34 y) and 4 naive depressant subjects (2 man and 2 woman, mean age: 30 y).All of the subjects based on DMS-IV criteria. Each subject intravenous bolus injection 4-[18F]-ADAM (185 MBq) using a 3D mode PET scanner. Except for visual inspection, the specific uptake ratio (SUR) of the raphe nucleus (RN), thalamus (TH), striatum (ST), frontal (FR) and occipital (OC) regions divided by cerebellum were measured in reference to the corresponding dedicated brain computerized tomography (CT). Results: In the Tri-Service General Hospital and Veterans General Hospital were consistent results. There were discernable uptakes of 4-[18F]-ADAM in the RN, TH, ST, FR and OC of the controls and less uptakes in naïve patients. A significant positive correlation was observed between 4-[18F]-ADAM SERT binding in the RN, ST, TH, FR, OC and HAMD in the drug naive depressant subjects. Conclusion: The brain distribution of 4-[18F]-ADAM in humans appears correlated with the known distribution of SERT. To our knowledge, this is the first clinical report in the world of F-18-ADAM PET in healthy and depressant subjects. Our results suggest that the 4-[18F]-ADAM PET might be a useful tool in assessing status of human brain SERT.