The Functionalization and Application of Nanodiamond

• Main Authors: Wen-Wei Cheng, 鄭文瑋
• Other Authors: Chin-Piao Chen
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/dbjf2p

碩士 === 國立東華大學 === 化學系 === 96 === The surface on 3~5 nm nanodiamond was successfully modified by several chemical methods, including esterification, saponification, coupling and substitution. Various functional groups form on nanodiamond by covalent bond. The analogues of vitamin K3 (2) and paclitaxel have been reported to have very potent anticancer activity. The nanodiamond conjugated with the analogues of vitamin K3 and paclitaxel also perform anticancer activity. The application of nanodiamond on solid-phase peptide synthesis was also achieved. The nanodiamond was charaterized by FTIR, NMR, TEM, FESEM, AFM, EA and PXRD. Heterogeneous asymmetric catalysts supported on nanodiamond were synthesized. Because of the effect of water on nanodiamond, the direct asymmetric Aldol reaction was investigated. The best reaction conditions are the use of room temperature, without solvent and additive. Numerous aromatic aldehydes were used in the asymmetric Aldol reaction with cyclohexanone, and the enantioselectivities were from 67% to 87% in the yields of 2% to 9%.