| Summary: | 碩士 === 國立中央大學 === 光電科學研究所 === 96 === The main purpose of this paper is to build a novel method to quantify the extent of nociceptive responses by using a our BBVS system. After induce a needle pressure stimulate on Yang Ling Quan of the left hind leg of a male mouse and then alleviation on the instep of left hind leg CMT points , the muscle vibration and Brain activity variation in mice was monitored and analyzed.
The study of pain always have technique problem: specially in awake animals. Philosophically, pain cannot be monitored directly in animals and the young baby but can only be estimated by examining their responses to nociceptive stimuli. However, such responses do not necessarily mean that there is a concomitant sensation. In addition, the absence of verbal communication in animals is undoubtedly and obstacle to the evaluation of pain. There are circumstances during which there can be little doubt that an animal and the young baby is feeling pain-notably when it is responding to stimuli through vocal responses such as squealing groaning or crying. On the other hand it is far more different to verify that at a given moment, an animal and the young baby feel no pain because it is presenting no typical physical signs or overt behavior. Therefore, we developed a new approach :BBVS(Brain Body Vibration, System) to measure the nociceptive responses by monitoring the paint point muscle vibration (by Laser) and the Brain reaction(by Pet). This new approach will quantitatively express the degree of pain.By using the same system we can measure the degree of reduced pain.The CMT(Collateral and Meridian Therapy) is often considered an appropriate model for clinical pain studies because such therapy can stop nociceptive stimulus effectively.The result showed that Brain wave activity and paint point muscle vibration change according to induce a needle pressure stimulate and the later CMT point alleviation. Thus, the BBVS system could be a good choice for quantitive analysis pain.
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