Enhancing the sensitivity and application of quartz crystal microbalance by nano-structured surface modification
碩士 === 國立交通大學 === 奈米科技研究所 === 96 === A quartz crystal microbalance (QCM) is a micro-mass-detection device that operates based on the piezoelectric properties of quartz crystals. Part I : A nanoparticle detection system was constructed by cross-linking antibodies onto the gold electrode of quartz cry...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2008
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| Online Access: | http://ndltd.ncl.edu.tw/handle/86249458191745031988 |
| Summary: | 碩士 === 國立交通大學 === 奈米科技研究所 === 96 === A quartz crystal microbalance (QCM) is a micro-mass-detection device that operates based on the piezoelectric properties of quartz crystals.
Part I : A nanoparticle detection system was constructed by cross-linking antibodies onto the gold electrode of quartz crystal microbalance (QCM). The sensitivity of gold nanoparticle detection was118 Hz . Surface structured modification of quartz crystal microbalance (QCM) binding to gold nanoparticle was characterized by atomic force microscopy (AFM). The current study provides the first example of detected nanoparticle sensor by piezoelectric sensor showing high sensitivity and specific to gold nanoparticle.
Part II : In this research, a method that amplified the quartz crystal microbalance (QCM) signals was found which gold nanoparticles were used to conjugate H5N1 and FMDV peptide for quartz crystal microbalance (QCM) detection signals could be amplified more than 200%. H5N1 membrane protein with gold nanoparticles conjugate could be detected and the signals could be amplified about 300% in our system.
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