Preparation, characterization, and platelet adhesion of gamma-poly(glutamic acid)-modified aliphatic poly(ester ureathane)s

• Main Authors: Bo-chen Chen, 陳柏誠
• Other Authors: Jui-che Lin
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/59028061790208808224

碩士 === 國立成功大學 === 化學工程學系碩博士班 === 96 === Aliphatic polyurethanes based on 1,6-hexanethylene diisocyanate, polycaprolactone and 1,4-butanediol were synthesized. The polyurethanes with different average length of hard segments were blended with various weight percentage of poly(γ-glutamic acid) (γ-PGA), a natural polymer, to improve their blood compatibility. The polymer's bulk, surface and platelet-contacting properties were studied using Fourier transform infrared spectrophotometry, differential scanning calorimetry, water absorption analysis, static contact angle analysis and in vitro platelet adhesion experiments. The effects of γ-PGA incorporation on the thermal transition property, hydrophilicity/hydrophobicity and platelet-contacting property of the polyurethanes are discussed. γ-PGA modified polyurethanes exhibit a lower melting temperature of hard segment domains, smaller contact angle, and higher water absorption value than the polyurethanes without γ-PGA. In vitro platelet adhesion studies indicated that the addition of γ-PGA into aliphatic polyurethanes leads to a reduction in platelet adhesion and activation.