| Summary: | 博士 === 國立中興大學 === 獸醫微生物學研究所 === 96 === “Emerging/reemerging Infectious Diseases Prevention” was the specific topic of World Health Day in 1997 from World Health Organization (WHO). In recent years, bacterial infection such as legionellosis (LG) and melioidosis (Mod) are thriving and emerging in Taiwan. These infectious diseases need do more studies in gravity. Therefore, this study explored the epidemiology survey of LG and Mod diseases to carve out the panorama of these diseases in Taiwan.
This study was the prime one to confirm the relationship between the clinic cases of LG and the contagious sources in Taiwan. The study found out the suspecting resources of highly infectious environments from spa. Otherwise, the study found infrequent Legionella preumophila serogroup 2 (Lp2) from clinic cases. Furthermore, the study established the relationship and conducted between the virulence (lvh +and rtxA-) gene analysis with environment strains and patient carry with risk factor (male, alcoholism, and smoker ) by means of the epidemiology survey to explain the mortality rate of LG..
This study focused on the outbreak of Mod cases caused by super-strong typhoon in 2005 for the clinic research. The study found varied types (S1-S7) of Burkholderia pseudomallei (Bpm) in the subtropical zone (SubTZ) of Taiwan. In addition, this study provided the pristine evidence showing that different types of Bpm existed in different SubTZ and temperate zone (TemZ) areas. The Bpm in TemZ (S2 and S7) can prevent the communication in the future and the advantage type (S1 and S3a) of Burkholderia pseudomallei in SubTZ can apply in the vaccine in Taiwan. Moreover, this study conducted further analyses in the high-prevalence area in the Er-Ren River Basin which was the first report for the high Bpm separation rate observed in 20 degrees north latitude 20o N. This report also demonstrated that the incidence rate of Bpm had correlation with the Bpm in soil, the seropositivity rate (A region was 36.6%, B region was 21.6%, and C region was 10.9%) from dwellers, and seropositive titers. The distribution of seropositive titers was significantly associated with the incidence rate of melioidosis (120, 68, or 36 incidence cases per 100,000 population in region A, B, or C in 2005), whereas it did not correlate with the geographical distribution of B. pseudomallei within the soil. Moreover, the media for Bpm in Taiwan correlated to the problem of flooding or behavior of having walked barefoot on soil.
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