Synthesis and Characterization of BSQDA for NO Molecular Imaging

• Main Authors: Yen-Hao Chen, 陳彥豪
• Other Authors: Yun-Ming Wang
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/99594763681710018019

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 96 === Nitric oxide is an ubiquitous messenger molecule in human body. In order to study the molecular image of nitric oxide, we make efforts in synthesis of the nitric oxide fluorescence probe, BSQDA. Some important fragments (compound 4 and 11) are synthesized, and the further synthetic steps are continuing. In addition, the longitudinal relaxivity (r¬1) of the dinitrosyl iron complex, [PPN][(S(CH2)3S)Fe(NO)2], is 0.03 mM?{1s?{1. It shows contrast property to enhance the signal intensity in MRI even at low magnetic field (20 MHz). For the [Gd(DTPA)(H2O)]2?{, the longitudinal relaxation times between [Gd(DTPA)(H2O)]2?{ and [Gd(DTPA)(H2O)]2?{ with NO are identical. It means that it’s probably hard to replace the inner sphere water of [Gd(DTPA)(H2O)]2?{ for NO.