Synthesis and Characterization of Penta-Copper/Silver-Thiolate Complex with Dithiol Ligand

• Main Authors: Tso-Yu Lin, 林佐諭
• Other Authors: Zhi-Neng Hsu
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/56864843514774716078

碩士 === 高雄醫學大學 === 醫藥暨應用化學系碩士班 === 96 === Copper is an essential element in all living organisms, serving as a cofactor for many important proteins and enzymes involved in electron transfer, oxidase and oxygenase activities and detoxification of oxygen radicals. The metallochaperone proteins deliver copper ions to specific physiological partners by direct protein-protein interactions. The Atx1-like chaperones transfer copper to intracellular copper transporters, and the CCS chaperones shuttle copper to copper, zinc superoxiede dismutase. In this work, we had synthesized a series of novel clusters containing copper(I) and silver(I) with the NS2 donor ligand. [PPh4][(C7H7NS2)3Cu5](12), [PPh4][(C8H9NS2)3Cu5] (13)and [Na][(C8H8S2)2Cu](14) were synthesized from their corresponding ligands.Thoes new compounds have been characterized by x-ray, mass and NMR spectroscopy. Those copper compounds and their transformation may help us to mimic the copper chaperone behavior.