Synthesis and Biological Activities of Amide Derivatives of 2-(6-Aryl-3(Z)hexen-1,5-diynyl)anilines
碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 96 === Compounds 24, 30, 40 and 41 displayed good growth inhibition activity against various human cancer cell lines and the average GI50 values of these compounds are from 0.19 10-6M to 31.2 10-6M. These compounds also arrested K-562 cells in the G2/M phase and indu...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2008
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| Online Access: | http://ndltd.ncl.edu.tw/handle/01371795963133328616 |
| Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 96 === Compounds 24, 30, 40 and 41 displayed good growth inhibition activity against various human cancer cell lines and the average GI50 values of these compounds are from 0.19 10-6M to 31.2 10-6M. These compounds also arrested K-562 cells in the G2/M phase and induced apoptosis . Comparing to the apoptosis area (31.57%) caused by compound 40 , it showed almost four times higher than control (7.5%) in 50 10-6M.
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