| Summary: | 碩士 === 高雄醫學大學 === 天然藥物研究所 === 96 === Antrodia cinnamomea, an endemic fungus in Taiwan, is well-known as a folk medicine, it grows only on the inner heartwood wall of the endemic evergreen Cinnamonum kanehirai and can not be cultivated. It has much physiological activities, including antioxidant, anticancer and hepatoprotective activity, and has active constituents that have anti-hepatitis B virus activity. The purpose of this research is to evaluate the hepatic protective effect of solid fermented A. cinnamomea against carbon tetrachloride (CCl4)-induced acute and chronic hepatic injury in vivo. In the acute liver injury experiment (go for three days)：after oral administration of solid fermented A. cinnamomea raw material suspension and ethanol extract and hot water extract, respectively, the results showed a significant decrease of GOT, GPT and LDH levels in mice serum compare to the carbon tetrachloride group. The raw material group showed the significant inhibition of liver lipid peroxidation induced by the carbon trichloride radical. In the chronic liver injury experiment (go for eight weeks)：raw material of solid fermented A. cinnamomea significantly decreased the level of serum GOT, GPT and LDH, and also inhibit liver lipid peroxidation. Ethanol and water extracts of solid fermented A. cinnamomea can decrease the blood LDH level significantly. These results demonstrated that solid fermented A. cinnamomea may exist hepatoprotective effect against acute and chronic chemical-induced heapatic injury in vivo, by mediating antioxidative and free radical scavenging activities.
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