| Summary: | 碩士 === 高雄醫學大學 === 公共衛生學研究所 === 96 === 英文摘要
Background
Some studies had pointed out that different obesity indices ,like BMI , Waist , WHR and WSHT, have different correlation with cardiovascular diseases. Previous studies also discovered that cytokines are secreted by adipose tissue (namely Leptin , IL-6 , TNF-α) and the other cytokines are secreted by non-adipose tissue (namely Ghrelin and CRP) possibly cause to have higher risk of cardiovascular disease among obese subjects . Therefore, we want to discuss the difference of cardiovascular risk factors and cytokines between the obesity and the non-obesity, also understand the effects of different obesity indices and weight loss on cardiovascular risk factors and cytokines.
Study design
Our study is a clinical trial study design , the study period is from March , 2007 to May, 2008. All subjects come from the community or the hospital in Kaohsiung, all of them includes thirty-five obesity (BMI≧27) and thirty-nine non-obeisty (BMI < 25). The controls were matched sex and age(± 5 years) to obese subjects . We measure and compare the differences of physic compositions and cytokines between the obese and the non-obese subjects. Furthermore, the obese subjects attended a weight control course to explore the effects of weight loss on cardiovascular risk factors and cytokines.
Results
We find the blood pressures , blood glucose , TG , Insulin and HOMA in obese group are significant higher than in control group. We also find leptin and CRP concentrations in obese group are higher than in non-obese group but ghrelin concentration of obese subjects is lower than that of non-obese subjects .
After weight loss, we find cardiovascular risk factors (Blood pressure , cholestrerol , TG , Insulin and HOMA) and cytokine (leptin) levels reduce significantly but ghrelin and IL-6 levels increase significantly. All of the four obesity indices have positive correlation with HOMA by running linear regression models. BMI’s coefficient of determination is the highest for Leptin (r2 = 81.3%) and Waist’s coefficient of determination is the highest for TNF-α (r2 =5.4%). WSHT’s coefficient of determination is the highest for Ghrelin and CRP (r2 =34.5% and r2 =5.4% subsequently). Moreover we also find WHR’s coefficient of determination is the lowest in the five cytokines.
Conclusion
In our study, we find cardiovascular risk factors and cytokines in obese group are significant higher than in non-obese group. We also find the effect of weight loss can improve cardiovascular risk factors and levels of cytokines. And we also find different obesity indices have different coefficients of determination for cytokines.
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