| Summary: | 碩士 === 中臺科技大學 === 醫學工程暨材料研究所 === 96 === Three-dimensional porous bioglass-ceramic scaffolds played an important role in bone defect. Replication technique could fabricate scaffolds interconnect well and high porosity. The glass powder 45S5 and MgO-CaO-Al2O3-SiO2-P2O5 were developed by Hench and the laboratory respectively. The biocompatibility was evaluated by means of the MTT test. The cell adhesion was observed by SEM. An optimum slurry ratio was deion water : 100 ml, PVA : 5 g, glass powder : 50 g. In the cell culture, the MG-63 was adhesion well whether on MgO-CaO-Al2O3-SiO2-P2O5 bulk or scaffolds. Bioactive glass 45S5 is used with superior effect in vivo, testing of the same material could be
adverse to cells because of pH increases over the buffered range of medium in vitro. Scaffolds fabricated by MgO-CaO-Al2O3-SiO2-P2O5 had higher compressive strength than 45S5. The factor affected compressive strength was porosity mainly.
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