| Summary: | 碩士 === 中山醫學大學 === 營養學研究所 === 96 === Hyperuricemia is a getting severe healthy problem in Taiwan because it is strongly associated with diabetes, obesity, hypertension. In most patients, hyperuricemia leads to enhanced oxidation and inflammation, and finally causes cardiac and kidney damage. Ancient Chinese medicine indicated that Dioscorea spp. with special benefit to kidney may provide protective and therapeutic effect to improve hyperuricemia.
Our past study has found that the intake of Dioscorea spp. could effectively reduce plasma uric acid level in normal mice, thus we think this food is helpful for patient with hyperuricemia. However, we used only one kind of Dioscorea spp.. We wish to study the protective and therapeutic effect of Dioscorea spp. in hyperuricemia by using three species of Dioscorea spp.. In this study, the influence of Dioscorea spp. intake upon the activity of xanthine oxidase, oxidative and inflammatory stress, as well as the kidney function will be examined.
The results of this study will provide new findings regarding the application of Dioscorea spp., including the information of specie for reducing uric acid level and maintaining kidney function. These data can be used for promoting cultivation, and business of Dioscorea spp..
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