| Summary: | 碩士 === 中山醫學大學 === 營養學研究所 === 96 === Many studies have proved that the dietary intake of macronutrientsincluding carbohydrate, protein and lipid is strongly related to the pathological development of obesity, metabolic syndromes or type 2 diabetes mellitus. On the contrary micronutrients such as minerals or vitamins do not provide energy in the food, and their physiological roles have therefore long been neglected. Recent evidences have shown that these minerals and vitamins actually play important roles in regulating energy homeostasis, and may consequently contribute to the status of metabolic syndromes. For example, the second most abundant intracellular divalent cation, magnesium, has involved in more than 300 metabolic reactions in the body, and lower serum concentration of magnesium has been proved to be strongly associated with the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus. Similarly, vitamin D, previously regarded as bone-related vitamin, is now proved to be a negative regulator of the rennin gene. Decreased vitamin D serum level may contribute the rennin-angiotensin system, and insulin resistance. It is therefore the aim of this study to evaluate the relationship between the dietary intake of the minerals and vitamins of the subjects with impaired glucose tolerance or type 2 diabetes mellitus. A total of 358 patients who visited National Taiwan University Hospital Yun-Lin Branch for general Health check-up, between February 2006 and April 2007, have been recruited in this study. Our results demonstrated that, within the indicators of metabolic syndrome, systolic blood pressure ( SBP ) is significantly related to the dietary intake of calcium and vitamin B6, while diastolic blood pressure ( DBP ) is significantly related to the intake volume of calcium, vitamins B1, B2, B5, and B6. For blood sugar level, our results demonstrated that dietary fiber, fat, vitamin E are significantly associated. Total cholesterol was associated with the intake of vitamin B12. Both high-density-lipoprotein ( HDL ) and low-density-lipoprotein ( LDL ) serum levels were associated with the intake volume of zinc. In addition, the level of HDL was associated with the intake volume of vitamins B5 and B6, while LDL was with those of vitamin B12.In summary, our data indicated that sufficient dietary intake of minerals and itamins may prevent the development of metabolic syndromes.
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