The expressions of human glutathione and catalase in erythrocyte during the menstrual cycle

• Main Authors: Wan-Ling, 蘇琬玲
• Other Authors: Jer-Yuh Liu
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/41236176131866161050

碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 96 === The purpose of this study is to investigate the correlation between estrogen and antioxidants such as (Glutathione GSH, catalase) in the erythrocytes. The total number population of this study was consistanted of 59 healthy persons (43 female and 16 male).The female group was divided into 2 groups according menstrual cycle: group A consisted of 16 female (10-20 days after menstrual cycle) is in the stage of higher estrogen level ; group B consisted of 27 females （1-9 and 21-30 days after menstrual cycle）is in the lower estrogen level. The results showed that the glutathione GSH level in group A (4.4±2.3 μg/mg) was significantly higher than that in group B (3.2±1.8 μg/mg) (P＜0.05). however the catalase level in group A (210±72 IU/mg) was also significantly higher than that in group B (168±62 IU/mg) (P＜0.05). The estrogen level in group A (184±106 pg/mL) is higher than that in group B (105±56 pg/mL) (P＜0.01). According to the average estrogen 134pg/mL the higher estrogen level group C (n=13) and lower estrogen level group D (n=29). The samples were divided is to two groups. There is no difference of Glutathione level between group C (4.0 ±1.6 μg/mg) and group D (3.5±2.2 μg/mg). However there is significant difference of catalase level between group C (217±78 IU/mg) and group D (167±60 IU/mg) (P＜0.05). No difference of antioxidants was observed in between male and female. Thus we suggested that the expression of antioxidants (Glutathione and catalase) in erythrocyte is correlated with the level of estrogen.