The study of Anti Aging on The permeablity of Epidermis

• Main Authors: Chun-mei Chiu, 邱春玫
• Other Authors: Yon-tern Wang
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/98919402477828571882

碩士 === 嘉南藥理科技大學 === 化妝品科技研究所 === 96 === In this project the spectrophotometry was used for monitoring Anti aging materials on a static state open system of Permeablity of epidermis which including two chambers, one is donor, the other is receptor and there is a pig skin membrane between them. The purpose here, we wanted understanding if the chose different Anti- aging materials are performed on human skin what will be happened. There are four kinds of anti-aging compound, which are popular in the cosmetic market, including Idebenone, Coenzyme Q10, Astaxanthin, and Alpha-Lipoic acid right now. These materials that were above mentioned were made to be an emulsion with a kind of surfactant for help them to be absorbed through the skin. In the donor chamber, Anti-aging materials have been resolved in normal saline, water, o/w type emulsion, and olive oil etc. And the other side of skin membrane inside the receptor chamber was fill with normal saline respectively during the tests. The wavelength of Idebenone, Coenzyme Q10, Astaxanthine, and Alpha-Lipoic acid at 406 nm, 400nm, 460nm, and 490nm were selected to determine the concentrations of anti-aging compounds in side the chambers were been changed due to the permeablity of epidermis. The results of every hour of the solution inside the donor chamber and receptor chamber were were determined by spectro-photometry during the period time of eight hours. Based on the results we found that, o/w emusion is the best kind of type products to apply the anti-aging materials. On the other hand in o/w emulsion, the concentration of anti-aging compounds inside the receptor chamber is keeping in high level and could have the best stability among the type of solution that we have done.