Synthesis and antimicrobial properties of poly(1-vinyl-3-Alkyl imidazolium) salts

• Main Authors: Hsuan-Yu Lin, 林宣妤
• Other Authors: Wen-Yueh Ho
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/24754886910271852795

碩士 === 嘉南藥理科技大學 === 化妝品科技研究所 === 96 === This study is focused on the antiseptic effect of poly(ionic liquid)s. Although a great diversity of synthetic antibacterial all have their own specific characteristics and also been used widely in recent years. However an antibacterial with broad, excellent and low-toxic behaviors is still under demand. Poly(ionic liquid)s, which is also known as a green solvent, was used for the antiseptic capability studies. Alkyl bromide polymer was first synthesized from 1-vinylimidazole, the product was then undergoing an anion exchange reaction at room temperature; two types of anion polymers (PF6－, BF4－) were found after purification. The antimicrobial result of Disc-surface assay showed that P(C8ImBF4) has the best efficiency in all of five microorganisms, especially in gram-positive bacteria (B. subtilis) but not for the gram-negative bacteria. In general, PF6－ series of poly(ionic liquid)s had the worst antimicrobial effect within three anion group. The minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of P(C2ImBr) are 5 and 7 mg/mL for B. subtilis, 2 and 5 mg/mL for C .albicans, individually. The experimental result, water affinity partial P(C4ImBr) is better than the P(C2ImBr) antibacterial effect, but the sparse water type experiment result is best antibacterial of ability by the P(C2ImBr). Our experimental data showed that the different length of carbon chain and anion type have the very tremendous influence regarding microorganism''s inhibitory action.