Design and Simulation of the Plasma Extraction Biochip Based on MicrochannelStructures
碩士 === 國立中正大學 === 機械工程所 === 96 === The clinical separation technique of blood cells and plasma (cell-free serum) from the whole blood is currently based on large facility such as a centrifuge. However, the disadvantage of this process is that the patients must have an assay in the hospital or labor...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2008
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| Online Access: | http://ndltd.ncl.edu.tw/handle/17514283910337894508 |
| Summary: | 碩士 === 國立中正大學 === 機械工程所 === 96 === The clinical separation technique of blood cells and plasma (cell-free serum) from the whole blood is currently based on large facility such as a centrifuge. However, the disadvantage of this process is that the patients must have an assay in the hospital or laboratory where there is the facility. The usage of disposable microfluidic chips is attractive because patients can monitor the conditions of the body at home easily. The goal of this study is to design the microchannel structure on chips numerically in which applying the theory of plasma-skimming effect to different geometric structures on the microchannel. The present study adopted the methods in separating the plasma and blood cell. The plasma-skimming effect is utilized at the branch of microchannel and the cell-free plasma near the wall of the main channel flows into the side channel; therefore, the plasma could be separated from the whole blood. The plasma is separated in terms of this mechanism, result of the examination could prevent from the influence of blood cell interference. The numerical simulation was performed by CFD-ACETM herein to analyze the effects of inlet velocity and the structures of the microchannel on the flow field and back–flow in the microchannel as well as the efficiency of separation and the mass flow rate of plasma collection. Therefore, the optimal structure could be found upon the present work.
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