Protein folding-The study of Go model

• Main Authors: Hsin-Lin Chiang, 江欣霖
• Other Authors: Chai-Yu Lin
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/33602104021846320661

碩士 === 國立中正大學 === 物理所 === 96 === Recent experiment results suggest that the native fold, or topology, plays a primary role in determining the transition from unfolded to folded states. To investigate the topological control of the folding process, we study the folding of a protein called Lysozme. The Hamiltonian is constructed by using a Go potential to retain the information about the native structures but reduce the energetic frustration. By the simulations of molecular dynamics, the heat capacity and the related thermodynamic functions are obtained. We find the simulation results are consistent with experiments.