Chemical process and application of γ-PGA polymer hydrogel

• Main Authors: Izu-Lung Lin, 林資隆
• Other Authors: Wen-Chang Liaw
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/62943155554369625730

碩士 === 國立雲林科技大學 === 化學工程與材料工程研究所 === 95 === In this study, hydrogels based on crosslink between poly(g-glutamic acid) (PGA) networks and polyvinyl alcohol(PVA) were prepared by Gamma Ray Irradiation.These hydrogels showed a pH- sensitive swelling behavior by –COOH group. Characterization of the resulting PGA/PVA hydrogel was performed including water absorption, FTIR, thermal gravity analysis (TGA), and Field Emission-Scanning electron microscopy (FE-SEM). The results show that the water absorptivity increased with the content of PGA.FTIR was used to determine the structure and composition of the PGA/PVA hydrogel. The shape was determined by FE-SEM was found to be a porous structure.Results of TGA show that the thermal stability increased with the content of PGA. The possibility to employ the prepared hydrogel as a pH-sensitive drug delivery system (DDS) has been investigated. In particular, amoxicillin, chosen as a model drug,has been entrapped into the PGA/PVA hydrogel, and in vitro release studies have showed that its release rate depends on different swelling of the network as a function of the environmental pH.