| Summary: | 碩士 === 國立陽明大學 === 醫學工程研究所 === 95 === Hippocampus is a prominent component of the central nervous system (CNS) and is involved in a variety of functions, including spatial mapping, learning and memory. As the structural changes in the hippocampus lead to brain disorders, such as Alzheimer’s disease, schizophrenia and melancholia, the detection of abnormality in hippocampus may contribute to early diagnosis and the potential therapy for brain diseases. Conventional investigation, e.g., autopsy and histology, was invasive and impossible for long-term study. The presented study was aimed to non-invasively and in vivo image the hippocampal subregions by using high-resolution diffusion weighted imaging (DWI). Further, the apparent diffusion coefficient (ADC) measurements along three orthogonal diffusion directions were applied to quantitatively evaluate the correlation between diffusion anisotropy and developmental changes in hippocampal subregions. The development of an in vivo detection tool to monitor detailed structural changes in hippocampus could provide a new insight into the pathogenesis in hippocampal subregions.
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