THE APPLICATION OF THERMO-SENSITIVE HYDROGELS ON ULTRASOUND THERMAL THERAPY

• Main Authors: Yi-Zheng Xiao, 蕭義正
• Other Authors: Hong-Sen Kou
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/zvx79a

碩士 === 大同大學 === 機械工程學系(所) === 95 === According to studying, to heat above 42℃ that the survival rate of a cell will decrease rapidly. It gives an evident description about the heat induced cell killing effect, which shows that cell killing is dependent on the temperature and the exposure duration. This treatment utilizes the highly focused ultrasonic energy to steer into human’s tissues. the temperature at the focal region can be raised. To reach the treatment’s objectives. An ultrasonic experimental systems was built. We used Poly(N-isopropylacrylamide)(Poly(NIPAAm))thermo-sensitive hydrogels in reversible color change in response to small temperature changes around its low critical solution temperature (LCST). To found ultrasound of the lesion’s size and position when different time and power. By the lesion’s size, we can recognize the ultrasonic temperature distributions. We added Acrylic acid(AAc) for increase LCST. So we can recognize any ultrasonic temperature distributions. We added nanoparticles, in order to increase hydrogels of attenuation coefficient. The temperature distributions can improve ultrasound thermal therapy.