| Summary: | 碩士 === 大同大學 === 生物工程學系(所) === 95 === The aim for the research is to encapsulate arbutin by liposome based on
non-phospholipids “ascorbyl palmitate”, and then perform transdermal
delivery experiments by adjusting different factors, such as different drug
concentrations, encapsulating lipids, surfactants etc. Furthermore, we got the
physical data, such as permeability coefficients, skin-drug accumulation, and
so on.
From the result, we observed that the releasing rate of 5% arbutin
liposome and 5% non-encapsulated arbutin solution are 19.60nmol/cm2/h
and 14.79nmol/cm2/h respectively. It means the encapsulation of arbutin has
enhancing effects for transdermal delivery. By adjusting different drug
concentration, we observed that releasing rate rises with concentration under
saturation concentration range. The best formulation is 5% arbutin and it
comes to the number of 19.60nmol/cm2/h. By adjusting different surfactants,
DA is the best formulation and it comes to 26.32 nmol/cm2/h. By adjusting
different lipids, it showed that the lipid did not affect the release.
In conclusion, the non-phospholipids “ascorbyl palmitate” has effects in
improving the transdermal delivery efficiency and we could also apply it to
other drugs to investigate the behaviors for delivery in the future.
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