Studies of the bioactive constitutents of solanum lyratum Thunb. cultivated in Taiwan.

• Main Authors: Tun-Wen Ku, 古惇文
• Other Authors: 徐鳳麟
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/63813391785133114122

碩士 === 臺北醫學大學 === 生藥學研究所 === 95 === The whole plants of Solanum lyratum Thunb. were extracted with methanol. By means of various column chromatographies, eightteen compounds were isolated and purified. The structure of these compounds were elucidated including five flavonoids: 1 (3,3'',4'',7-tetramethoxymyri cetin), 2 (3,3'',7- trimethoxyquercertin), 3(3,4''-dimethoxyfkampferol), 4 (3,3'',7-trimethoxymyricetin), 5 (3-methoxykampferol); four phenolics: 6 (Scopoletin), 7 (Methylcaffeate), 8 (Vanillin) and 9 (p-Hydroxybezalde hyde); one?namide: 10 (N-(trans-Feruloyl)tyramine);two indoles: 11 (indole-3-carboxaldehyde), 12 (indole-3-carboxylic acid); five steroidal glycosides 13 and 14 (β-Sitosterol 3-O-β-D-glucopyranoside and β-Stig masterol 3-O-β-D- glucopyranoside), 15 (Soladulcine B), 16 (Tigogenin 3-O-lycotetraoside), 17 (Tigogenin 3-O-lucotrioside) and 18 (Proto- desgalactotigonin). In addition, the cytotoxic activity of the isolated constituents against MCF-7 and HepG2 was evaluated. Results show that compound 15 and 16 have cytotoxicity in the concentration 10 μg/ml against MCF-7, compound 15 and 17 have potent cytotoxicity in 10 μg/ml against HepG2. Compound 15 were first evaluated the potent cytotoxicity to the literatures.