| Summary: | 博士 === 臺北醫學大學 === 藥學研究所 === 95 === A healthy life must consist of the three followings: nutrition, maintenance of health and cultivation. Overconsumption has been a precautious and concerning issue nowadays. Maintenance of health and cultivation must be based on a good establishment and promotion of health care, medical concept, and risk perception. Should we stop selling and breeding of contaminated seafood? Should a mother eat seafood during their pregnancy? Do health foods really provide only nutrition but other harmful effects? Is there any potential endanger risks during weight reduction? These controversial issues always take place along with our daily life but there are still many people lack of the sense of risks. In addition, people exposed to these risks don’t know what or how to do to reduce the risks. Therefore, we investigate the risk perception of weight reduction products and behaviors of general public. Besides that, we also investigate the degree of weight loss, differences of body composition, leptin concentration and superoxide dismutase (SOD) activities after a body weight reduction (BWR) regime.
General public and personnel participated in the BWR regime held in a medical center are the study subjects. A questionnaire was filled in under a free will and 452 valid questionnaires are collected. Following the questionnaires, 165 BRW regime participants were selected for further blood sample analysis. Our results indicated that people worry about physical and functional risks on weight reduction products and behaviors rather than social and time risks. Fear for purchasing counterfeit merchandise, side-effects and also care about buying the merchandise that is not counter valuable as it was claimed. People recognize that asking for doctor’s recommendation, choosing a seller they deal with and choosing a reliable seller are effective approaches to reduce risk. In contrary, they recognize that products under advertising promotion and represented by artists are less effective.
Prior to the BWR regime, female leptin concentrations and RBC-SOD activities were significantly higher than in males (p<0.001; p<0.05). The BWR regime resulted in a significant decrease in body weight and BMI in both males and females (p<0.001) and significant changes in body composition variables such as body fat mass, waist and hip circumferences (p<0.001). Following the BWR program, leptin concentration decreased significantly (p<0.01) in females and males, respectively. The RBC-SOD activities increased significantly (p<0.01) in females and males, respectively, after the BWR regime. Three possible explanations exist that account for the increase in SOD activity: (A) oxidative stress produced by exercise during the BWR regime; (B) enhanced anti-oxidative ability after losing weight; and, (C) oxidative stress produced by plasma leptin is strongly correlated with SOD as RBC-SOD activity increased as plasma leptin levels reduced. Weight reduction following the BWR regime were negatively correlated with initial leptin (p<0.001). We summarized a linear regression equation that can predict a weight loss of 8.13-3.78 kg with the initial leptin concentration of 5-30ng/ml after 8-week BWR program.
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