Effects of rice bran supplement on glycated hemoglobin and insulin sensitivity in type 2 diabetic patients.

• Main Authors: Lee Hsiou-Li, 李秀利
• Other Authors: Cheng Hsing-Hsien Ph.D
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/13777162885397319929

碩士 === 臺北醫學大學 === 保健營養學系 === 95 === Plasma adiponectin concentration is lower and plasma resistin and c-reative protein concentration is higher in type 2 diabetes mellitus than euglycemic human. Therefore, the aim of this study was to observe the effect of rice bran flour supplementation for 12 weeks on the concentrations of plasma glucose, glycated hemoglobin (HbA1C), adiponectin, resistin, and c-reactive protein concentration, and insulin sensitivity in type 2 diabetes mellitus. This study was designed as randomized, double-blind and crossover trials. Twenty-four type 2 diabetes subjects in Lo-Tung Pohai hospital in Yilan, 5 men and 19 women aged 30 to 80 years volunteered to participate. The subjects were randomized to two sequences that included 5 weeks of treatment with 38 g of rice bran flour and rice flour. Treatment was preceded by a 14-day washout period. During intervention periods, subjects did not change their dietary habit, the physical condition, and the kinds of medicine and amounts of medicine. On the beginning, 5, 7 and 12 weeks, oral glucose tolerance test were conducted. The results showed rice bran flour supplementation, plasma fasting glucose concentration and HbA1C level was significantly decreased 10.8% and 2.5%, respectively. Plasma adiponectin concentration in RB group was significantly increased compared with baseline (P < 0.05). Insulin sensitivity index (HOMAIR) was tended to decrease (-5.8%, P = 0.09) in RB group. In conclusion, type 2 diabetic patients supplementation 38 g of rice bran flour every day for 5 weeks were significantly decreased 2.5% HbA1C and 10.8% plasma fasting glucose, and significantly increased 9.6% plasma adiponectin concentration.