Studies on the Chemical Constituents and Biological Activities from the Stem of Pourthiaea lucida and the Root of Strychnos cathayensis

• Main Authors: Yu-Ting Luo, 羅玉婷
• Other Authors: Jih-Jung Chen
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/96448272316347650266

碩士 === 大仁科技大學 === 製藥科技研究所 === 95 === As a series of studies on the chemical constituents and biological activities of Formosan plants, the stem of Pourthiaea lucida (Rosaceae) and the root of Strychnos cathayensis (Loganiaceae) were investigated. A new dibenzofuran, lucidafuran (1) and 8 known compounds were isolated and characterized from the stem of P. lucuda. The known compounds included a dibenzofuran, eriobofuran (2), two biphenyls, aucuparin (3), 2’-methoxyaucuparin (4), five steroids, stigmast-5-en-3β,7β-diol (5), β-sitosterol (6), stigmasterol (7), β-sitostenone (8) and stigmasta-4,22-dien-3-one (9). In addition, investigation of an EtOAc-soluble fraction of the root of S. cathayensis has led to the isolation of a new indole alkaloid, 11,12-dimethoxyhenningsamine (10) and seventeen known compounds, including two indole alkaloids, 12-hydroxy-11-methoxyhenningsamine (11), 11-methoxyhenningsamine (12), three benzenoids, syringic acid (13), p-hydroxybenzoic acid (14), trans-p-coumaryl aldehyde (15), two coumarins, aesculetin dimethyl ether (16), 6,7,8-trimethoxycoumarin (17), a 2-quinolone, 4-methoxy-1-methyl-2-quinolone (18), a α-tocopheranoid, α-tocopheryl quinone (19), two fatty acids, oleic acid (20), stearic acid (21), eight steroids, β-sitosterol (6), stigmasterol (7), 3β-hydroxystigmast- 5-en-7-one (22), 3β-hydroxystigmasta-5,22-dien-7-one (23), 6β-hydroxy- stigmast-4-en-3-one (24), and 6β-hydroxy-stigmasta-4,22-dien-3-one (25). The structures of the isolates were elucidated by spectral analyses and comparison of their physical and spectral data with literature. Compounds 1 and 10 are new compounds. Compounds 1 and 3 exhibited potent inhibition against fMLP-induced superoxide production with IC50 = 18.70 ± 4.40 and 17.04 ± 6.80μΜ, respectively. In addition, compound 3 exhibited marked antitubercular activity with MIC of 6.25μg/mL against Mycobacterium tuberculosis H37Rv.