新丹參內酯類似物之合成與其抗乳癌活性之研究

• Main Authors: Tseng shiau ting, 曾筱婷
• Other Authors: 林立錦
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/81094050191087186180

碩士 === 中國文化大學 === 應用化學研究所 === 95 === The dried roots of Salvia miltiorrhiza under the name Danshen has been used in traditional Chinese medicine for treatment of cardiovascular disease, hemorrhage, menstrual disorder, miscarriage, and swelling. According to literature reports, a lot of tanshinones were isolated and identified from S. miltiorrhiza and many of them have been also reported to exhibit diverse biological activities such as antitumor, antioxidant, and antiplatelet aggregation. Recently, a new component, neo-tanshinlactone, was isolated from S. miltiorrhiza in our laboratory, and showed selective anti-breast cancer activity. Because this compound might be a useful lead for developing novel anti-breast cancer drug candidate, in this thesis we synthesized analogues of neo-tanshinlactone and studied the structure and anti-breast cancer activity relationship.