| Summary: | 碩士 === 國立臺灣科技大學 === 高分子系 === 95 === This study investigated the biomedical characteristics and physical properties of a composite material consisting of a mixture of water-soluble chitosan (WSC) and aqueous polyurethane (WPU).
Because synthetic anionic WPU acquires a carboxylic acid group, it is highly compatible with blood. While WPU is flexible, chitosan is hard and brittle when in a dry state. As a consequence, aqueous polyurethane can be used to give flexibility and softness to chitosan. Our experiments verified that increasing WSC content causes the tensile strength of the WSC/WPU mixture to increase. And elongation increases with WPU content. We also varied the amount of NaOH used to assess the anticoagulant properties of the WPU/WSC mixture. Our experimental results showed that platelet adhesion and protein adsorption increased with WSC content. The mixture can therefore reduce plasma protein absorption and platelet activity and adhesion. An activated partial thromboplastin time test (APPT) showed that APTT increases in a linear fashion, exerting an anticoagulant effect, with increasing WSC content.
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