| Summary: | 碩士 === 國立臺灣大學 === 電機工程學研究所 === 95 === The purpose of this thesis is to investigate the potential to acquire in vivo metabolic information using non-water suppressed magnetic resonance spectroscopy (NWS-MRS) technique. The use of NWS MRS is necessary when water suppression is not applicable for serious susceptibility and motion. As well, NWS MRS is potentially convenient for absolute metabolites concentration quantification.
First, we correct the temporal phase and frequency drifts during MRS scans using internal water signal in the NWS MR spectra. The use of NWS method significantly improves the quality of in vivo MRS without prolong scan time. The successful application of the developed techniques to high quality in vivo MRS is demonstrated.
Second, a time–domain MRS fitting method “filter-diagonalization method” (FDM), is proposed for the quantification of “non-water suppressed” MR spectra. Based on our simulation studies, the stability and robustness of FDM method is comparable to other time-domain methods. Furthermore, the phantom and in vivo experiments showed that the FDM enables the quantification of metabolic information in water suppressed (WS) and NWS MR spectra respectively.
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