| Summary: | 博士 === 國立臺灣大學 === 電機工程學研究所 === 95 === Magnetic Resonance Spectroscopy (MRS) has been used for almost three decades to investigate the living tissue for prognostic or diagnostic markers. Fast magnetic resonance spectroscopy imaging technique, PEPSI, can reduce the long scan time of conventional SI to a single minute, which significantly raise the clinical potential of SI. In this thesis, a PEPSI sequence suitable for general clinical application has been implemented on the clinical machine at various field strengths. We investigate the possibility to combine PEPSI with parallel imaging techniques to further improve the temporal resolution of SI. The experiments showed that the parallel acceleration on PEPSI is feasible with the enrollment of multiple array coils to achieve sub-minute measurement. With the current developed large-N array coils, the temporal resolution of SI can be further reduce. Beneficial from the fast property of PEPSI technique, spatial distributed metabolite T2 relaxation time can be derived in clinical acceptable time. Consistent and reliable results were observed using the proposed protocol based on PEPSI sequence. The acquisition of less than 30 minutes is potentially applicable in clinical practice.
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