| Summary: | 碩士 === 國立臺灣大學 === 生理學研究所 === 95 === The aim of this study is to evaluate the period of fish oil supplement could prevent the breast cancer incidence studied in DMBA (7,12-dimethylbenzanthracene) induced Sprague-Dawley rat. Maternal diet was given with linoleic acid-rich sunflower oil at stage of fetus to lactation without or with fish oil supplement at stage of fetus to lactation, at age of puberty, or at age of adult for 42 days. Spatial memory performance was examined by Morris water maze at age of 195 days. Animals were scarified at the age of 223 days old.
It was found that maternal dietary sunflower oil intake did increase the % of cumulative breast cancer incidence in their female offspring. While, the breast cancer incidence was reduced 50% in their female offspring via maternal fish oil supplementation during pregnancy and lactation. The fish oil supplementation during puberty did delay but not inhibit the breast cancer promotion. It is interesting to know that fish oil may enhance tumor growing, since the tumor size was larger in animals with fish oil supplementation. The spatial memory performance was improved in the animals with fish oil supplementation.
It was concluded that maternal fish oil supplementation during pregnancy and lactation may be the critical period for the breast cancer prevention on their female offspring, while, fish oil supplementation during puberty may delay the breast cancer happening.
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