The release of cisplatin from mesoporous materials

• Main Authors: Wei-Chun Chen, 陳韋均
• Other Authors: Hsiu-Mei Lin
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/84375349332064000825

碩士 === 國立臺灣海洋大學 === 生物科技研究所 === 95 === There is an increasing interest in optimizing the efficacy of drug activity by using rationally designed and prepared drug carrier materials, and many efforts have recently been devoted to design and prepare sustained and controlled drug-release systems. Amorphous colloidal and porous silica are used as adjuvants in pharmaceutical technology. The advantages of using silica species as a drug carrier system are their nontoxic nature, high stability, and good biocompatibility. Mesoporous silica materials, MCM-41 and SBA-15 have attracted much attention, owing to their novel properties, such as large surface area, highly regular and unique tunable nanometer pore sizes, and tailorable surface chemical properties, which qualify them as very promising candidates for multifunctional drug carriers. Cisplatin, a drug which could suppress cell histiocytosis, is also a kind of antineoplastic agent. We use MCM-41 or SBA as drug carrier for cisplatin .In Stimulated stomach pH 1.2 solution, We confirmed that cisplatin in mesoporous materials would pass stomach entirely . Moreover, MBT-2 cell uptake cisplatin by endocytosis pathway, and the uptake maximum appear in 5 hours.