| Summary: | 碩士 === 國立臺灣師範大學 === 化學系 === 95 === In one part, we investigated a new tripodal, trimethyl-2-naphthol-capped gallamide dendritic dimer are synthesized via click chemistry. After methylation with the dendritic dimmer, it possessed six side of quaternary ammonium groups which increased solublility. When photoinduced, it transferred to o-quinone methide (o-QM) intermediate. Meanwhile, photo-cross-links of DNA by irradiation with light under mild conditions and without any additives., and reducing agents will offer considerable potential in clinical. We use agarose gel electrophoresis and AFM to observe the result of cross-links. It aggregated because that beta-naphthol ammonium-capped dendritic dimmer worked efficiently. In part two, we derivated vanadyl(V) complexes that we have reported in 2005 to investigate two new complexes , iminostilbene and quinoxaline. After they were photoduced, the transient indicate the involvement of LMCT with concomitant tautomerization, leading to a distinctive, o-quinone methide-type V-bound hydroxyl species that is responsible for the observed photocleavage profiles. The resonace of π-π bonding of flat template legand chelated to DNA efficiently. We can demonstrate the good results from agarose gel electrophoresis.
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