Alignment of Collagen by Magnetic Nanoparticle and Synthesis of Hollow Polyaniline Capsules

• Main Author: 何峙鋒
• Other Authors: Chia-Chun Jay Chen
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/46097629778394313067

碩士 === 國立臺灣師範大學 === 化學系 === 95 === Extracellular matrixes such as bone, skin, cornea, and tendon have ordered structures composed of large amount of collagen. How to alignment collagen and change it’s structure is very important in biological and medical application. Here, we demonstrated a methodology to arrange the structure of collagen by FePt magnetic nanoparticle. The conformation of collagen was analyzed and investigated by transmission electron microscope (TEM)、circule dichroism spectroscopy (CD)、Multiphoton autofluorescence. In the other experiment. A double-surfactant layer assisted polymerization method was designed to prepare well-controlled core/shell metal oxide/polyaniline (c/s-MO/PANi) nanocomposites. The monodispersed and uniform core/shell nanocomposites including c/s-CuO/PANi, -Fe2O3/PANi, -In2O3/PANi and -Fe2O3/SiO2/PANi were successfully prepared using this polymerization method. By the removal of the cores for the resulting c/s-MO/PANi nanocomposites, hollow PANi capsules with different shapes and sizes were obtained. Our method provides a facile and effective way to design novel core/shell nanostructures with diverse functionality and high colloidal stability