Study the relationship of amino acid sequences and nucleotide sequences in productive HCV strains

• Main Authors: Shiou-jiuan Shr, 施秀娟
• Other Authors: Koun-Tem Sun
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/28575199316451434537

碩士 === 國立臺南大學 === 數位學習科技學系 === 95 === A major etiological agent of post-transfusion hepatitis is caused by HCV, which has been widespread globally. Vaccine development has been hampered by a high degree of antigenic variation and a lack of protection against viral reinfection. At present, some researches on the virus replication consider some cells and virus factors assisting together. What role does it play on each virus replication in HCV is the most important issue. In our research, we apply data mining technology-「Association rule」 to find the covariation relationship between coding (NS2、NS3、NS5B) and non-coding (3’UTR、5’UTR) region from 225 full-length hepatitis C virus sequences which come from「Los Alamos HCV sequence database」.We locate some covariation relationships from association rule technology, and they are corresponded to the regions about HCV replications which we survey from literatures. In a summary, the contribution in our research is that we design a fast analytical technology for finding some covariation relationship between coding and non-coding regions.