分子內Diels-Alder反應應用於天然物GuanacastepeneA之七、六駢環合成研究

• Main Author: 鄭家任
• Other Authors: 沙晉康
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/41719290853811294487

碩士 === 國立清華大學 === 化學系 === 95 === Guanacastepene’s activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis makes it of interest as a potential lead compound in the development of new antibacterial agents. We prepare trienyl compounds by combining side chain of the diene with 3-methylcyclohept-2-enol. We form the cyclohexane ring by an intramolecular Diels-Alder reaction, which has been used to form related [5, 4, 0]undecane. Now, we have the part of the carbon skeleton of Guanacastepene A. Finally, we study the influence of methyl group of dienophile on intramolecular Diels-Alder reaction