Optimal Selection of Beam Orientations in Intensity Modulated Radiation Therapy

• Main Authors: Ru-Siou Yu, 余如修
• Other Authors: Ue-Pyng Wen
• Format: Others
• Language: en_US
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/83259720265854471430

碩士 === 國立清華大學 === 工業工程與工程管理學系 === 95 === Radiation therapy is a common and important treatment for some specific tumors in the treatment of cancer. At present, a new development of radiation therapy is being generated, namely, the intensity modulated radiation therapy (IMRT). IMRT modulate the intensity of the radiation beam to focus on a higher radiation dose to the tumor while minimizing radiation exposure to surrounding normal tissues. The technology and equipment of radiation therapy have already been quite developed at present. However, selecting appropriate beam orientations is manually completed by a planner according to his (her) experience and intuition in current clinical practice. The purpose of this thesis is the optimal selection of the beam configuration by considering the beam orientation completely. Besides the radiation dose limit to the tumor and the adjacent organs needed to be satisfied, we take the dose distribution into consideration and optimize the beam configuration and beam intensity simultaneously. In addition, we accelerate the speed of optimization by the limits of the geometric spacing to make the treatment plan of selecting beam orientations meet radiation therapy in clinical. Furthermore, the proposed model compared with the equi-spaced model provides the optimal beam configuration to help physicists in decision-making.