| Summary: | 博士 === 國立體育學院 === 體育研究所 === 95 === This research involves two studies, the first study was to investigate the effects of arginine supplementation on antifatigue. In this randomized, double blind, crossover study, twelve healthy subjects took either a placebo or an arginine supplement 0.2g/kg-wt for a total of 28 days, followed by a 14 days washout period; and then resumed the arginine supplement or placebo. After supplement period, they performed a single bout of exercise to exhaustion. Blood samples were collected before exercise, at exercise 15min, at exhaustion and 20, 60, and 120 minutes during the recovery period. In vivo proton magnetic resonance spectroscopy (1H-MRS) was used to measure creatine levels in Soleus and Tibialis Anterior muscle before and after arginine supplementation.
It was observed that exercise time to exhaustion was significantly higher in the arginine group compared to that in the placebo group. The lactate concentration at exhaustion was higher in the arginine group compared to that in the placebo group. Additionally, the glucose levels at 60, and 120 minutes of the recovery period were significantly higher in the arginine group compared to those in the placebo group. There were no differences in plasma ammonia, creatine kinase, free fatty acid, O2 pulse, or creatine levels in Soleus and Tibialis Anterior muscle between treatments. The results indicated that arginine supplementation before an exhaustive exercise could enhance exercise performance and physiological recovery in humans. It demonstrated that ingestion of arginine essence offers anti-fatigue benefits after exhaustive exercise.
The second study was to investigate the effects of arginine supplementation on acute metabolic responses during recovery after a single bout of endurance exercise in trained athletes. Twelve healthy male judo athletes were randomly divided into two groups and performed a single bout of exercise at a speed estimated to correspond to 75% VO2max for 60 minutes, and then took either a placebo or arginine at 0.1g/kg-wt. Blood samples of each athlete were collected before exercise, and 0, 15, 30, 45, 60, 90, 120 minutes after exercise, respectively. The experiment was repeated two weeks later, but treatments were exchanged for two groups. The concentrations of glucose, insulin, free fatty acid (FFA), glycerol, lactate, ammonia, creatine kinase, IL-6 and NOx (NO2- + NO3-) in blood were examined. No differences in the levels of glycerol, lactate, ammonia, creatine kinase, IL-6 or NOx between the two groups were observed at any of the time points. However, the concentration of glucose was significantly higher in the arginine group, compared to that in the placebo group at the 15 minutes recovery period. The insulin concentration was higher in the arginine group compared to that in the placebo group at the 30 minutes recovery period. Furthermore, the free fatty acid levels at 30, and 45 minutes recovery periods were significantly lower in the arginine group compared to those in the placebo group. The results indicate that arginine supplementation during exercise recovery period could increase glucose and insulin concentrations, and increase FFA availability in muscle.
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