| Summary: | 碩士 === 國立成功大學 === 醫學工程研究所碩博士班 === 95 === Diabetes mellitus is a highly prevalent disease among the elderly of Taiwan and worldwide. Reportedly, one out of five persons aged 65 years and older suffers this illness, a constellation of chronic disorders, diabetic vasculopathy including diabetic foot and a resultant osteomyelitis is one of the most common one; approximately 47% of the amputation are due to diabetes. Thus, medical care of diabetic foot and infections on diabetics has become an important clinic issue in our ageing society. Most of western countries including United States and European Union have devoted to much research on the pathogenesis and relevant infections in diabetic feet; by comparison, there are very few in Taiwan. The aim of this study is to apply the photo-electronic technology to develop a non-invasive measurement system for microcirculation measurement system based on photoplethesmography (PPG) and laser Doppler flowmetry (LDF) techniques. With the system, we could monitor the changes of blood volume and blood velocity in the diabetic lower limbs. The research was mainly divided into two parts. The first part was the setup of the dual-channels measurement system. We expected it to monitor the changes of blood volume and blood velocity both collected simultaneously from the right and left lower limbs. At present, the correlation coefficient R2 between the indexes of the flow meter's velocity <ω> and practically velocity of blood mimicking fluids had reached a high linear relation of 0.97. In the second part, we measured the human microcirculation signals. Till now, the self-designing non-invasive measurement system for microcirculation could acquire the changes of blood volume and blood velocity in human’s fingers and lower limbs. In addition, there were significant differences in blood volume and blood velocity signals between bilateral sites of fingers or lower limbs by using this system, when applying a pressure to cuff one site of upper arm or leg by using a pressure cuff. In the clinical data analyzing, we found out that the pulse timing differences between pulse peaks in the bilateral lower limbs’ great toe PPG pulses could figure out whether patients has vascular diseases in the lower limbs (P < 0.05).
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