| Summary: | 碩士 === 國立成功大學 === 航空太空工程學系碩博士班 === 95 === Extracorporeal Shock Waves (ESW) are routinely used for non-invasive disintegration of stones within the human body. In the recent years, ESW has other applications such as treatment in orthopedics. It was successful in clinical treatments of musculo-skeletal disorders. Consequently, the study of applying ESW for destroying fat tissue is a pioneer trial in the development of a shockwave-assisted lipotripsy technology.
In in-vitro experiments, pressure sensors were used to measure the pressure field inside a pig’s fat with different operational voltages. High-energy shock waves with an energy flux density of approximately 0.873 mJ/mm2 were applied to the treated fat tissue. This value of energy flux density corresponds to an operation voltage of 10kV in our laboratory. After the ESW treatment, we observed the treated fat tissue with pathological examination through the processes of formalin fixing, paraffin-embedding, and hematoxylin & eosin staining. We observed destructions on the treated fat tissues by a microscope and took pictures of the observed specimens. Three different magnifications (12, 40 and 100 times) were used to examine the physical, structural, and histological variation of adipose cells after shock wave treatment. It was found that, for the treated fat cells, the mechanical effect and cavitation effect caused by shock wave focusing occur in a specific area within the subcutaneous layer, results in broken membranes of the adipose tissues but induces no harm on the skin layer, near-by blood vessels, and peripheral nerve fiber. It was found that the required number of shock waves at least 650 with energy flux density of approximately 0.873 mJ/mm2 is for visible damages on the treated fat tissue.
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