| Summary: | 碩士 === 國立成功大學 === 化學系碩博士班 === 95 === Abstract
A series of chromatographic separations of the methanolic extract of Machilus philipinensis Merr. has led to the isolation of forty-three compounds. Among these isolates, forty compounds were characterized by comprehensive analyses of their 1D and 2D NMR and mass spectral data. They include thirteen neolignans:
cinnamophilin, biscinnamophilin, oleiferin D, meso-dihydroguaiaretic acid, lyoniresol, lyoniside, dehydroguaiaretic acid, machilupin A and B, machiphilin A, machilutone A, machilutone B and 9,9'-Ο-diferuloyl-seco-isolariciresinol; three flavonoids: (-)-epicatechin, (+)-epicatechin, and (+)-catechin; three coumarins: scopoletin, isofraxidin, and scopolin; ten benzenoids: methyl syringate, 3,4,5-trimethoxyphenyl-β-D-glucopyranoside, 5,6-dimethoxybenzene-1,3-diol, 4'-
hydroxy-2, 3-dihydrocinnamic acid, syringic acid, vanillic acid, (E)-ferulic acid octacosyl ester, methyl-4-hydroxybenzoate, 2,4,6-trimethoxyphenol, and homovanillyl alcohol; two amides, namely N-trans-feruioyl tyramine, and N-cis-feruioyl tyramine; three isoquinolines: tetrahydroisoquinolinone, 6,7-dimethoxyisoquinoline, and thalifoline; one ionones: grasshopperketone; three sesquiterpenes: sesquichamaenol, machilusoxide A and B; and two sterols: namely β-sitosterol and β-sitosteryl glucoside. Among them, machilupin A and B, machilusoxide A and B were new compounds. Compounds, machiphilin A, and machilutone A and B were reported for the first time new skeleton from the natural source.
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