Predicting the function of hydrolase proteins based on the recognition of motifs

碩士 === 中興大學 === 資訊科學系所 === 95 === Protein plays an important role in organisms. Protein has many kinds of function, for example: transportation, sports, enzymes, immunization, support, protection, etc. After the Human Genome Project had been completed, the discovery of protein function becomes an im...

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Bibliographic Details
Main Authors: Kuan-Chi Wang, 王冠棋
Other Authors: 曾怜玉
Format: Others
Language:zh-TW
Published: 2007
Online Access:http://ndltd.ncl.edu.tw/handle/75383120891911865867
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Summary:碩士 === 中興大學 === 資訊科學系所 === 95 === Protein plays an important role in organisms. Protein has many kinds of function, for example: transportation, sports, enzymes, immunization, support, protection, etc. After the Human Genome Project had been completed, the discovery of protein function becomes an important work. The method that uses biological experiments can achieve the most accurate results in finding the function of a protein. But lots of money and time are needed to find the functions of so many proteins. Therefore, predicting the function of a protein by computer is an important research issue. The computer methods in predicting protein function can be divided into three classes: methods based on sequences, methods based on structures, and methods that combine the previous two. In this thesis, a method based only on sequences to predict the protein function was proposed. This method predicts functions by recognizing the motifs containied in the sequence. In order to test the proposed method, an experiment has been conducted to predict the seven subfunctions of hydrolase proteins. The accuracy achieved is above 99%.