Physical characteristics and biocompatibility of chitosan-gold and chitosan-silver nanocomposites

• Main Authors: Yu-Bin Chang, 張昱彬
• Other Authors: 徐善慧
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/95858509411898805134

碩士 === 中興大學 === 化學工程學系所 === 95 === Chitosan nanocomposites were prepared by addition of 5 nm gold nanoparticles or silver nanoparticles in the chitosan-Au and chitosan-Ag matrix. The growth of human gingival fibroblasts on chitosan nanocomposites was enhanced. Chitosan-silver nanocomposites had the better antibacterial effect for Staphylococcus aureus. Results from Atomic force microscope showed that the surface crystalline domains of chitosan-Au or chitosan-Ag nanocomposites appeared larger at 60 or 120 ppm. At this time the mechanical properties and the glass transition temperature of the nanocomposites measured by the dynamic mechanic analyzer showed that chitosan-Au at 60 ppm and chitosan-Ag nanocomposites at 120 ppm were better. Transmission electron microscopy showed that aggregation of the nanoparticles at high concentrations may have destroyed the crystalline domains and reduced the physical properties. The free scavenging ability and hydrophilicity of the nanocomposites were better than those of the pure chitosan.