Studies of NanoBiomaterials for Wound Dressings

• Main Authors: Chih-Wei Chou, 周志謂
• Other Authors: 徐善慧
• Format: Others
• Language: en_US
• Online Access: http://ndltd.ncl.edu.tw/handle/88576184054124288843

博士 === 國立中興大學 === 化學工程學系所 === 95 === Abstract The skin is the largest organ of the body, ranging from 1.2 to 2.0 m2 in an adult. The skin consists of epidermis and dermis. The primary functions of the skin are to guard the body from harmful environment and to prevent the excessive loss of body fluid and electrolytes. The loss of skin in injuries breaks the integrity of this biological barrier. Therefore, early coverage of the freshly excised wounds is important in treatment. An ideal wound dressing should be non-antigenic, biocompatible, durable, adherent, readily available and inexpensive. In this study, we have prepared a polyether-type waterborne polyurethane (PU) incorporated with different amounts of gold nanoparticles (17.4-65 ppm) or silver nanoparticles (30.2-113 ppm). The nanocomposite containing 43.5 ppm of gold or 30.2 ppm of silver was found to possess optimal thermal and mechanical properties, and much reduced foreign body reactions in subcutaneous rats and pig. The nanocomposite at 43.5 ppm of gold (“PU-Au 43.5 ppm”) and that at 30.2 ppm of silver (“PU-Ag 30.2 ppm”) exhibited greater thermal and mechanical properties and biostability as well as reduced foreign body reactions in rats and pigs. In particular, evidence of oxidative chain scission and crosslinking of the surface was present in the explanted specimens other than PU-Au 43.5 ppm and PU-Ag 30.2 ppm in pig model, shown by ATR-IR spectra. PAA/clay and P(AA-co-IA)/clay nanocomposite hydrogels were successfully synthesized. Some conclusions can be made from the preceding discussion as follows: the greater the content of the clay, the lower the swelling ratio of the gels. The XRD patterns showed that, in the hydrogels, the clay was exfoliated. The gel thermostability of the gels were enhanced by adding clay into the gel composition, attributed to the crosslinking formed between the gel matrix and clay dispersed phase through in situ polymerization. The possibility of applying of these nanocomposites for the development of wound dressing has been confirmed.