Development of a novel thermogelling and mucoadhesive liquid suppository for site-targeting delivery of anti-colorectal cancer drugs

• Main Authors: Pei-Heng Lai, 賴沛亨
• Other Authors: Yie -Wen Chien
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/91682320675761930449

碩士 === 高雄醫學大學 === 藥學研究所碩士班 === 95 === Colorectal cancer is the third leading cause of cancer death in the United States, while in Taiwan, it ranks Top 3 In the cancer mortality rate. Curcumin, a major ingredient in the popular spice - curry, is derived from the rhizome of curcuma longa. It has shown anti-cancer activity in a variety of cancer cell lines derived from breast, cervical, colon, gastric, hepatic, leukemia, oral epithelial, ovarian, pancreatic and prostate as well as in the animal models. To study the potential of Poloxamer 407 as the Thermogelling and mucoadhesive polymer for development of a site-targeting delivery system to enhance the localized delivery of curcumin to the colorectal cancer. The mucoadhesive strength and rheological properties were first measured as a function of Poloxamer concentrations. The gelation temperature of Poloxamer 407 was found to vary with its concentration and become gelling at 37℃ at the concentration of 15.5%. To ensure gelation at physiological temperature after intra-rectal application. Gelation temperature was determined by rheological measurement as well as by its physical appearance. The results indicated that its mucoadhesive strength also shows a dependency on temperature, which appears to be related to the increment in the Maximum Strength and Average Strength of the polymer. To assure that Poloxamer 407 is biocompatible to the target tissue, its cytotoxicity against the colorectal cancer cells was evaluated and the results suggested that it is nontoxic to 5 primary colon cancer cells for up to 200mg/mL . The results have suggested that Poloxamer 407 could be a potential thermogelling and mucoadhesive polymer for the development of a site-targeting colorectal DDS.